Exosome component 5

PDB rendering based on 2nn6.

Available structures
PDB	2nn6

Identifiers

Symbols

EXOSC5; MGC111224; MGC12901; RRP41B; RRP46; Rrp46p; hRrp46p; p12B

External IDs

OMIM: 606492 MGI: 107889 HomoloGene: 5981 GeneCards: EXOSC5 Gene

Gene Ontology
Molecular function	• 3'-5'-exoribonuclease activity • RNA binding • exoribonuclease activity • protein binding
Cellular component	• exosome (RNase complex) • nucleus • nucleolus • cytoplasm • cytosol • transcriptionally active chromatin
Biological process	• nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay • rRNA processing • RNA processing • RNA metabolic process • mRNA metabolic process • exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay • exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay • DNA deamination
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 19:
41.89 – 41.9 Mb

Chr 7:
26.44 – 26.45 Mb

PubMed search

[1]

[2]

Exosome component 5, also known as EXOSC5, is a human gene, which is part of the exosome complex.^[1]

Interactions

Exosome component 5 has been shown to interact with Exosome component 8^[2] and Exosome component 1.^[2]^[3]

References

^ "Entrez Gene: EXOSC5 exosome component 5". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=56915.
^ ^a ^b Raijmakers, Reinout; Egberts Wilma Vree, van Venrooij Walther J, Pruijn Ger J M (Nov. 2002). "Protein-protein interactions between human exosome components support the assembly of RNase PH-type subunits into a six-membered PNPase-like ring". J. Mol. Biol. (England) 323 (4): 653–63. doi:10.1016/S0022-2836(02)00947-6. ISSN 0022-2836. PMID 12419256.
^ Raijmakers, Reinout; Noordman Yvet E, van Venrooij Walther J, Pruijn Ger J M (Jan. 2002). "Protein-protein interactions of hCsl4p with other human exosome subunits". J. Mol. Biol. (England) 315 (4): 809–18. doi:10.1006/jmbi.2001.5265. ISSN 0022-2836. PMID 11812149.

Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
Allmang C, Petfalski E, Podtelejnikov A, et al. (1999). "The yeast exosome and human PM-Scl are related complexes of 3' --> 5' exonucleases.". Genes Dev. 13 (16): 2148–58. doi:10.1101/gad.13.16.2148. PMC 316947. PMID 10465791. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=316947.
Brouwer R, Allmang C, Raijmakers R, et al. (2001). "Three novel components of the human exosome.". J. Biol. Chem. 276 (9): 6177–84. doi:10.1074/jbc.M007603200. PMID 11110791.
Chen CY, Gherzi R, Ong SE, et al. (2002). "AU binding proteins recruit the exosome to degrade ARE-containing mRNAs.". Cell 107 (4): 451–64. doi:10.1016/S0092-8674(01)00578-5. PMID 11719186.
Raijmakers R, Noordman YE, van Venrooij WJ, Pruijn GJ (2002). "Protein-protein interactions of hCsl4p with other human exosome subunits.". J. Mol. Biol. 315 (4): 809–18. doi:10.1006/jmbi.2001.5265. PMID 11812149.
Brouwer R, Vree Egberts WT, Hengstman GJ, et al. (2002). "Autoantibodies directed to novel components of the PM/Scl complex, the human exosome.". Arthritis Res. 4 (2): 134–8. doi:10.1186/ar389. PMC 83843. PMID 11879549. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=83843.
Yang XF, Wu CJ, Chen L, et al. (2002). "CML28 is a broadly immunogenic antigen, which is overexpressed in tumor cells.". Cancer Res. 62 (19): 5517–22. PMID 12359762.
Raijmakers R, Egberts WV, van Venrooij WJ, Pruijn GJ (2002). "Protein-protein interactions between human exosome components support the assembly of RNase PH-type subunits into a six-membered PNPase-like ring.". J. Mol. Biol. 323 (4): 653–63. doi:10.1016/S0022-2836(02)00947-6. PMID 12419256.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
Lehner B, Sanderson CM (2004). "A protein interaction framework for human mRNA degradation.". Genome Res. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMC 442147. PMID 15231747. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=442147.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics.". Nature 433 (7021): 77–83. doi:10.1038/nature03207. PMID 15635413.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Zhou H, Zhang D, Wang Y, et al. (2006). "Induction of CML28-specific cytotoxic T cell responses using co-transfected dendritic cells with CML28 DNA vaccine and SOCS1 small interfering RNA expression vector.". Biochem. Biophys. Res. Commun. 347 (1): 200–7. doi:10.1016/j.bbrc.2006.06.093. PMID 16815301.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.

PDB gallery

2nn6: Structure of the human RNA exosome composed of Rrp41, Rrp45, Rrp46, Rrp43, Mtr3, Rrp42, Csl4, Rrp4, and Rrp40

Exosome component 5

Interactions

References

Further reading